| 1. Journée | 12.09.2021 | Boston River | - | Montevideo Wanderers | 1:3 | ||||
| 2. Journée | 17.09.2021 | Rentistas | - | Boston River | 1:2 |  |
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| 3. Journée | 26.09.2021 | Boston River | - | Peñarol | 2:5 | ||||
| 4. Journée | 03.10.2021 | Montevideo City Torque | - | Boston River | 4:3 |  |
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| 5. Journée | 10.10.2021 | Boston River | - | Villa Española | 1:0 | |
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| 7. Journée | 21.10.2021 | Boston River | - | Cerrito | 3:2 | |
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| 8. Journée | 24.10.2021 | Liverpool | - | Boston River | 2:2 | ||||
| 12. Journée | 14.11.2021 | Sud América | - | Boston River | 1:2 | |
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| 14. Journée | 30.11.2021 | Fénix | - | Boston River | 0:0 | |
Uruguay