| 1. Journée | 11.09.2021 | River Plate | - | Cerrito | 1:0 |  |
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| 2. Journée | 19.09.2021 | Liverpool | - | River Plate | 3:1 | |
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| 3. Journée | 25.09.2021 | River Plate | - | Deportivo Maldonado | 1:2 | ||||
| 4. Journée | 02.10.2021 | River Plate | - | Cerro Largo | 0:4 | ||||
| 5. Journée | 09.10.2021 | Progreso | - | River Plate | 1:0 | ||||
| 6. Journée | 16.10.2021 | River Plate | - | Sud América | 5:1 | ||||
| 7. Journée | 20.10.2021 | Plaza Colonia | - | River Plate | 0:0 | ||||
| 8. Journée | 25.10.2021 | River Plate | - | Fénix | 0:0 | |
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| 9. Journée | 30.10.2021 | Boston River | - | River Plate | 1:2 | ||||
| 10. Journée | 03.11.2021 | River Plate | - | Montevideo Wanderers | 0:1 | |
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| 12. Journée | 14.11.2021 | River Plate | - | Peñarol | 1:1 | ||||
| 13. Journée | 22.11.2021 | Montevideo City Torque | - | River Plate | 1:1 | ||||
| 14. Journée | 30.11.2021 | River Plate | - | Villa Española | 4:2 | ||||
| 15. Journée | 04.12.2021 | Nacional | - | River Plate | 4:2 |  |
Uruguay