| 1. Journée | 17.05.2021 | Cerrito | - | River Plate | 3:1 |  |
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| 2. Journée | 24.05.2021 | River Plate | - | Liverpool | 3:2 | |
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| 3. Journée | 30.05.2021 | Deportivo Maldonado | - | River Plate | 0:0 | |
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| 4. Journée | 06.06.2021 | Cerro Largo | - | River Plate | 2:4 | ||||
| 5. Journée | 12.06.2021 | River Plate | - | Progreso | 4:0 | ||||
| 6. Journée | 19.06.2021 | Sud América | - | River Plate | 1:2 | ||||
| 7. Journée | 22.06.2021 | River Plate | - | Plaza Colonia | 0:1 | ||||
| 8. Journée | 26.06.2021 | Fénix | - | River Plate | 3:4 | ||||
| 9. Journée | 03.07.2021 | River Plate | - | Boston River | 1:1 | ||||
| 10. Journée | 10.07.2021 | Montevideo Wanderers | - | River Plate | 1:2 | ||||
| 11. Journée | 17.07.2021 | River Plate | - | Rentistas | 0:0 | ||||
| 12. Journée | 01.08.2021 | Peñarol | - | River Plate | 2:0 | |
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| 13. Journée | 07.08.2021 | River Plate | - | Montevideo City Torque | 3:3 |  |
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| 15. Journée | 21.08.2021 | River Plate | - | Nacional | 2:0 | |
Uruguay