| 3. Journée | 01.02.2021 | Defensor Sporting | - | River Plate | 0:2 |  |
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| 4. Journée | 04.02.2021 | River Plate | - | Danubio | 0:4 | ||||
| 5. Journée | 08.02.2021 | Nacional | - | River Plate | 3:0 |  |
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| 6. Journée | 11.02.2021 | River Plate | - | Boston River | 3:1 | |
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| 7. Journée | 14.02.2021 | Deportivo Maldonado | - | River Plate | 1:2 | |
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| 8. Journée | 17.02.2021 | River Plate | - | Rentistas | 1:1 | ||||
| 9. Journée | 20.02.2021 | River Plate | - | Cerro Largo | 2:0 | ||||
| 10. Journée | 27.02.2021 | River Plate | - | Montevideo Wanderers | 1:1 | ||||
| 11. Journée | 07.03.2021 | Peñarol | - | River Plate | 2:0 | |
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| 12. Journée | 14.03.2021 | Liverpool | - | River Plate | 3:2 | ||||
| 13. Journée | 20.03.2021 | River Plate | - | Montevideo City Torque | 1:1 | ||||
| 14. Journée | 26.03.2021 | Plaza Colonia | - | River Plate | 1:0 |  |
Uruguay