| 3. Journée | 12.09.2021 | AC Reggiana 1919 | - | AS Gubbio | 0:0 |  |
|||
| 4. Journée | 18.09.2021 | AS Gubbio | - | Virtus Entella | 3:1 | ||||
| 5. Journée | 25.09.2021 | US Grosseto FC | - | AS Gubbio | 1:1 | |
|||
| 6. Journée | 28.09.2021 | AS Gubbio | - | Delfino Pescara | 2:2 | ||||
| 7. Journée | 03.10.2021 | Olbia Calcio | - | AS Gubbio | 1:0 | ||||
| 19. Journée | 19.12.2021 | AS Gubbio | - | Aquila Montevarchi | 1:0 | ||||
| 20. Journée | 22.12.2021 | AS Gubbio | - | Cesena FC | 4:1 | ||||
| 24. Journée | 30.01.2022 | AS Gubbio | - | US Grosseto FC | 0:0 | |
|||
| 25. Journée | 06.02.2022 | Delfino Pescara | - | AS Gubbio | 3:1 | ||||
| 26. Journée | 13.02.2022 | AS Gubbio | - | Olbia Calcio | 1:1 | |
|||
| 27. Journée | 16.02.2022 | US Pontedera | - | AS Gubbio | 0:0 | ||||
| 28. Journée | 20.02.2022 | AS Gubbio | - | SSD Città di Teramo | 2:2 | ||||
| 22. Journée | 23.02.2022 | AS Gubbio | - | AC Reggiana 1919 | 2:1 |  |
|||
| 38. Journée | 23.04.2022 | Aquila Montevarchi | - | AS Gubbio | 2:1 |  |
Italie