| 1. Journée | 16.07.2022 | Tacuary | - | Guaireña FC | 0:0 | ||||
| 2. Journée | 21.07.2022 | Tacuary | - | Cerro Porteño | 0:1 | ||||
| 4. Journée | 31.07.2022 | Tacuary | - | Club Olimpia | 2:1 | ||||
| 5. Journée | 06.08.2022 | General Caballero DJLM | - | Tacuary | 0:4 |  |
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| 6. Journée | 16.08.2022 | Tacuary | - | Resistencia SC | 1:1 |  |
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| 7. Journée | 21.08.2022 | 12 de Octubre de Itauguá | - | Tacuary | 0:2 | ||||
| 8. Journée | 29.08.2022 | Tacuary | - | Sol de América | 1:0 | ||||
| 9. Journée | 04.09.2022 | Club Nacional | - | Tacuary | 1:0 | ||||
| 10. Journée | 11.09.2022 | Tacuary | - | Guaraní | 2:0 | ||||
| 12. Journée | 19.09.2022 | Guaireña FC | - | Tacuary | 1:0 | ||||
| 13. Journée | 26.09.2022 | Cerro Porteño | - | Tacuary | 5:0 | ||||
| 14. Journée | 02.10.2022 | Tacuary | - | Sportivo Ameliano | 1:1 | ||||
| 15. Journée | 06.10.2022 | Club Olimpia | - | Tacuary | 1:0 | ||||
| 16. Journée | 12.10.2022 | Tacuary | - | General Caballero DJLM | 0:3 | ||||
| 17. Journée | 15.10.2022 | Resistencia SC | - | Tacuary | 0:3 | ||||
| 18. Journée | 22.10.2022 | Tacuary | - | 12 de Octubre de Itauguá | 5:1 | ||||
| 19. Journée | 26.10.2022 | Sol de América | - | Tacuary | 2:2 | |
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| 20. Journée | 31.10.2022 | Tacuary | - | Club Nacional | 2:1 | |
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| 21. Journée | 06.11.2022 | Guaraní | - | Tacuary | 2:1 |
Paraguay