| 1. Journée | 05.02.2022 | Club Olimpia | - | General Caballero DJLM | 2:2 |  |
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| 2. Journée | 13.02.2022 | Libertad | - | General Caballero DJLM | 1:0 | ||||
| 3. Journée | 20.02.2022 | General Caballero DJLM | - | Tacuary | 2:0 | ||||
| 4. Journée | 25.02.2022 | Sportivo Ameliano | - | General Caballero DJLM | 1:0 | ||||
| 5. Journée | 04.03.2022 | General Caballero DJLM | - | Club Nacional | 1:2 | ||||
| 15. Journée | 11.05.2022 | General Caballero DJLM | - | Sportivo Ameliano | 0:3 | ||||
| 16. Journée | 14.05.2022 | Club Nacional | - | General Caballero DJLM | 1:2 | ||||
| 17. Journée | 22.05.2022 | General Caballero DJLM | - | Guaraní | 0:4 | ||||
| 19. Journée | 17.06.2022 | General Caballero DJLM | - | Sol de América | 1:1 |  |
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| 20. Journée | 22.06.2022 | Cerro Porteño | - | General Caballero DJLM | 3:1 |  |
Paraguay