| 7. Journée | 11.09.2021 | MŠK Žilina | - | AS Trenčín | 1:3 | ||||
| 14. Journée | 05.11.2021 | AS Trenčín | - | MFK Zemplín Michalovce | 4:2 | ||||
| 15. Journée | 19.11.2021 | MFK Ružomberok | - | AS Trenčín | 3:0 | ||||
| 16. Journée | 27.11.2021 | AS Trenčín | - | FC DAC 1904 | 0:1 |  |
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| 17. Journée | 04.12.2021 | ŠKF Sereď | - | AS Trenčín | 4:2 | ||||
| 18. Journée | 11.12.2021 | AS Trenčín | - | MŠK Žilina | 1:3 | ||||
| 21. Journée | 19.02.2022 | Spartak Trnava | - | AS Trenčín | 0:0 | ||||
| 22. Journée | 26.02.2022 | AS Trenčín | - | Tatran Liptovský Mikuláš | 2:2 |
Slovaquie