| 1. Journée | 05.02.2022 | Tauro FC | - | Sporting San Miguelito | 3:3 |  |
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| 2. Journée | 13.02.2022 | Sporting San Miguelito | - | Plaza Amador | 1:1 |  |
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| 3. Journée | 20.02.2022 | Árabe Unido | - | Sporting San Miguelito | 0:0 | ||||
| 5. Journée | 05.03.2022 | Sporting San Miguelito | - | Potros del Este | 1:1 | ||||
| 6. Journée | 08.03.2022 | UD Universitario | - | Sporting San Miguelito | 0:2 | |
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| 7. Journée | 13.03.2022 | Sporting San Miguelito | - | Herrera FC | 1:1 | |
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| 8. Journée | 20.03.2022 | Veraguas United | - | Sporting San Miguelito | 1:2 | ||||
| 9. Journée | 26.03.2022 | San Francisco FC | - | Sporting San Miguelito | 0:1 | |
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| 11. Journée | 09.04.2022 | Sporting San Miguelito | - | Independiente de La Chorrera | 2:1 | ||||
| 13. Journée | 23.04.2022 | Plaza Amador | - | Sporting San Miguelito | 1:1 | ||||
| 14. Journée | 27.04.2022 | Sporting San Miguelito | - | Árabe Unido | 1:0 | ||||
| 15. Journée | 30.04.2022 | Sporting San Miguelito | - | Alianza | 1:0 | |
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| 12. Journée | 04.05.2022 | Sporting San Miguelito | - | Tauro FC | 0:1 | ||||
| 16. Journée | 07.05.2022 | Potros del Este | - | Sporting San Miguelito | 0:3 |
Panama