| 1. Journée | 03.07.2022 | Pumas UNAM | - | Club Tijuana | 1:1 |  |
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| 2. Journée | 09.07.2022 | Club Tijuana | - | FC Juárez | 0:2 |  |
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| 4. Journée | 24.07.2022 | Club Tijuana | - | CF América | 2:0 |  |
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| 5. Journée | 27.07.2022 | Atlas Guadalajara | - | Club Tijuana | 1:2 | |
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| 6. Journée | 31.07.2022 | Club Tijuana | - | Mazatlán FC | 2:0 | ||||
| 7. Journée | 07.08.2022 | Deportivo Toluca | - | Club Tijuana | 3:1 | ||||
| 8. Journée | 13.08.2022 | Club Tijuana | - | Puebla FC | 3:3 | |
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| 9. Journée | 18.08.2022 | Cruz Azul | - | Club Tijuana | 1:2 | ||||
| 10. Journée | 21.08.2022 | Gallos Blancos | - | Club Tijuana | 2:0 | ||||
| 13. Journée | 08.09.2022 | Club Tijuana | - | Deportivo Guadalajara | 1:2 | ||||
| 14. Journée | 12.09.2022 | CF Pachuca | - | Club Tijuana | 6:1 | |
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| 17. Journée | 03.10.2022 | Club León | - | Club Tijuana | 2:2 | |
Argentine