| 2. Journée | 17.05.2021 | Rio Grande Valley FC | - | San Antonio FC | 2:1 | ||||
| 2. Journée | 23.05.2021 | San Antonio FC | - | Birmingham Legion | 2:1 | ||||
| 2. Journée | 30.05.2021 | San Antonio FC | - | Rio Grande Valley FC | 1:1 | ||||
| 3. Journée | 06.06.2021 | Colorado Springs Switchbacks | - | San Antonio FC | 1:1 | ||||
| 3. Journée | 12.06.2021 | Las Vegas Lights FC | - | San Antonio FC | 1:1 | ||||
| 3. Journée | 17.06.2021 | New Mexico United | - | San Antonio FC | 2:0 |  |
|||
| 3. Journée | 20.06.2021 | San Antonio FC | - | Rio Grande Valley FC | 1:1 | |
|||
| 3. Journée | 27.06.2021 | Real Monarchs SLC | - | San Antonio FC | 1:1 | ||||
| 4. Journée | 04.07.2021 | San Antonio FC | - | Austin Bold | 0:1 | |
|||
| 4. Journée | 17.07.2021 | Colorado Springs Switchbacks | - | San Antonio FC | 2:3 | |
|||
| 4. Journée | 22.07.2021 | San Antonio FC | - | New Mexico United | 3:0 | ||||
| 4. Journée | 01.08.2021 | Austin Bold | - | San Antonio FC | 0:3 | ||||
| 5. Journée | 05.08.2021 | El Paso Locomotive | - | San Antonio FC | 2:0 |
Angleterre