| 1. Journée | 08.01.2022 | Club Tijuana [] | - | Club León [] | 3:2 | ||||
| 2. Journée | 15.01.2022 | Atlas Guadalajara [] | - | Club Tijuana [] | 1:2 |  |
|||
| 3. Journée | 22.01.2022 | Club Tijuana [] | - | Atlético San Luis [] | 5:0 | |
|||
| 4. Journée | 29.01.2022 | UANL Tigres [] | - | Club Tijuana [] | 2:0 | ||||
| 5. Journée | 05.02.2022 | Club Tijuana [] | - | Deportivo Guadalajara [] | 1:2 | ||||
| 6. Journée | 12.02.2022 | Mazatlán FC [] | - | Club Tijuana [] | 1:3 | |
|||
| 7. Journée | 19.02.2022 | Club Tijuana [] | - | CF Monterrey [] | 1:1 | |
|||
| 9. Journée | 05.03.2022 | Santos Laguna [] | - | Club Tijuana [] | 2:1 | ||||
| 11. Journée | 19.03.2022 | Deportivo Guadalajara [] | - | Club Tijuana [] | 3:0 | ||||
| 12. Journée | 26.03.2022 | Club Tijuana [] | - | UANL Tigres [] | 3:1 | ||||
| 13. Journée | 02.04.2022 | Club Tijuana [] | - | Atlas Guadalajara [] | 0:1 |  |
|||
| 14. Journée | 05.04.2022 | Atlético San Luis [] | - | Club Tijuana [] | 0:3 | |
|||
| 15. Journée | 20.04.2022 | Club Tijuana [] | - | Santos Laguna [] | 4:1 | ||||
| 16. Journée | 23.04.2022 | Club León [] | - | Club Tijuana [] | 2:1 | ||||
| 17. Journée | 30.04.2022 | Club Tijuana [] | - | Mazatlán FC [] | 4:0 | |
|||
| 18. Journée | 07.05.2022 | CF Monterrey [] | - | Club Tijuana [] | 1:0 |
Mexique