| 1. Journée | 12.09.2020 | Oldham Athletic | - | Leyton Orient | 0:1 | ||||
| 2. Journée | 19.09.2020 | Leyton Orient | - | Mansfield Town | 2:2 | ||||
| 4. Journée | 03.10.2020 | Leyton Orient | - | Cheltenham Town | 0:2 | ||||
| 16. Journée | 05.12.2020 | Scunthorpe United | - | Leyton Orient | 2:0 | ||||
| 17. Journée | 12.12.2020 | Leyton Orient | - | Newport County | 2:1 |  |
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| 18. Journée | 15.12.2020 | Morecambe FC | - | Leyton Orient | 2:1 | |
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| 19. Journée | 19.12.2020 | Leyton Orient | - | Crawley Town | 1:2 | ||||
| 20. Journée | 26.12.2020 | Cambridge United | - | Leyton Orient | 2:1 | ||||
| 21. Journée | 29.12.2020 | Leyton Orient | - | Southend United | 2:0 | |
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| 22. Journée | 02.01.2021 | Leyton Orient | - | Salford City | 1:0 | ||||
| 24. Journée | 16.01.2021 | Leyton Orient | - | Morecambe FC | 2:0 |  |
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| 26. Journée | 23.01.2021 | Leyton Orient | - | Forest Green Rovers | 0:1 |
Angleterre