| 1. Journée | 11.02.2022 | Unión de Santa Fe II | - | River Plate II | 0:0 | ||||
| 6. Journée | 10.03.2022 | River Plate II | - | Gimnasia de La Plata II | 2:4 | ||||
| 7. Journée | 18.03.2022 | River Plate II | - | Boca Juniors II | 0:0 | ||||
| 8. Journée | 01.04.2022 | Defensa y Justicia II | - | River Plate II | 2:0 | ||||
| 9. Journée | 09.04.2022 | River Plate II | - | Argentinos Juniors II | 0:0 | ||||
| 10. Journée | 14.04.2022 | Banfield II | - | River Plate II | 2:3 | ||||
| 11. Journée | 20.04.2022 | Talleres de Córdoba II | - | River Plate II | 1:1 | ||||
| 12. Journée | 25.04.2022 | River Plate II | - | Atlético Tucumán II | 4:0 | ||||
| 13. Journée | 29.04.2022 | Sarmiento de Junín II | - | River Plate II | 1:2 |  |
Argentine