| 5. Journée | 05.03.2022 | Atlético Palmaflor | - | CD Guabirá | 1:0 | ||||
| 6. Journée | 21.03.2022 | CD Guabirá | - | Royal Pari | 0:3 | ||||
| 7. Journée | 03.04.2022 | CD Guabirá | - | The Strongest | 1:3 | ||||
| 8. Journée | 10.04.2022 | Universitario de Sucre | - | CD Guabirá | 2:0 | ||||
| 9. Journée | 17.04.2022 | CD Guabirá | - | Club Aurora | 3:2 | ||||
| 10. Journée | 22.04.2022 | CD Guabirá | - | Real Santa Cruz | 1:0 |  |
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| 11. Journée | 24.04.2022 | CD Guabirá | - | Oriente Petrolero | 0:0 | ||||
| 12. Journée | 29.04.2022 | CD Guabirá | - | Nacional Potosí | 1:2 | ||||
| 13. Journée | 07.05.2022 | Royal Pari | - | CD Guabirá | 1:3 |  |
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| 14. Journée | 11.05.2022 | CD Guabirá | - | Atlético Palmaflor | 3:0 | |
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| 15. Journée | 14.05.2022 | The Strongest | - | CD Guabirá | 0:0 | |
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| 16. Journée | 20.05.2022 | CD Guabirá | - | Universitario de Sucre | 1:0 |
Bolivie