| 2. Journée | 30.07.2021 | Kolos Kovalivka | - | Metalist 1925 Kharkiv | 1:0 | ||||
| 5. Journée | 22.08.2021 | Kolos Kovalivka | - | FK Oleksandriya | 0:1 | ||||
| 6. Journée | 28.08.2021 | Dinamo Kiev | - | Kolos Kovalivka | 7:0 | ||||
| 7. Journée | 12.09.2021 | Kolos Kovalivka | - | FK Mariupol | 1:3 |  |
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| 8. Journée | 18.09.2021 | Inhulets Petrove | - | Kolos Kovalivka | 0:2 | ||||
| 9. Journée | 24.09.2021 | Kolos Kovalivka | - | Vorskla Poltava | 0:1 | |
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| 10. Journée | 02.10.2021 | Kolos Kovalivka | - | Chernomorets Odessa | 2:1 | ||||
| 13. Journée | 31.10.2021 | Kolos Kovalivka | - | FK Lviv | 0:1 | ||||
| 14. Journée | 07.11.2021 | Kolos Kovalivka | - | Shakhtar Donetsk | 1:3 | ||||
| 15. Journée | 21.11.2021 | Desna Chernigov | - | Kolos Kovalivka | 0:1 | |
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| 3. Journée | 24.11.2021 | FC Mynai | - | Kolos Kovalivka | 1:1 | |
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| 17. Journée | 04.12.2021 | Metalist 1925 Kharkiv | - | Kolos Kovalivka | 0:1 | ||||
| 18. Journée | 12.12.2021 | Kolos Kovalivka | - | FC Mynai | 2:1 |
Ukraine