| 3. Journée | 20.06.2021 | Columbus Crew | - | Chicago Fire | 2:0 | ||||
| 3. Journée | 24.06.2021 | Philadelphia Union | - | Columbus Crew | 1:0 | ||||
| 3. Journée | 28.06.2021 | Austin FC | - | Columbus Crew | 0:0 | ||||
| 4. Journée | 22.07.2021 | Columbus Crew | - | Nashville SC | 0:0 | ||||
| 4. Journée | 24.07.2021 | Atlanta United FC | - | Columbus Crew | 0:1 | ||||
| 4. Journée | 31.07.2021 | New York City FC | - | Columbus Crew | 4:1 | ||||
| 5. Journée | 05.08.2021 | Columbus Crew | - | D.C. United | 2:4 |  |
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| 5. Journée | 08.08.2021 | Columbus Crew | - | Atlanta United FC | 2:3 | ||||
| 5. Journée | 16.08.2021 | Chicago Fire | - | Columbus Crew | 1:0 | ||||
| 5. Journée | 19.08.2021 | New York RB | - | Columbus Crew | 1:0 | ||||
| 5. Journée | 21.08.2021 | Columbus Crew | - | Seattle Sounders | 1:2 |
Trinité-et-Tobago
