| 1. Journée | 11.09.2020 | Arsenal FC U23 | - | Southampton FC U23 | 1:2 |  |
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| 3. Journée | 26.09.2020 | Southampton FC U23 | - | West Ham United U23 | 2:2 |  |
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| 4. Journée | 03.10.2020 | Tottenham Hotspur U23 | - | Southampton FC U23 | 2:1 | ||||
| 5. Journée | 18.10.2020 | Southampton FC U23 | - | Blackburn Rovers U23 | 0:1 | ||||
| 8. Journée | 07.11.2020 | Southampton FC U23 | - | Manchester City U23 | 5:2 | ||||
| 10. Journée | 30.11.2020 | Southampton FC U23 | - | Brighton & Hove Albion U23 | 0:1 | ||||
| 11. Journée | 12.12.2020 | Southampton FC U23 | - | Leicester City U23 | 5:2 | ||||
| 14. Journée | 05.03.2021 | Southampton FC U23 | - | Arsenal FC U23 | 2:2 | |
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| 21. Journée | 15.03.2021 | Manchester City U23 | - | Southampton FC U23 | 7:1 | ||||
| 22. Journée | 21.03.2021 | Southampton FC U23 | - | Liverpool FC U23 | 1:2 | ||||
| 15. Journée | 12.04.2021 | Chelsea FC U23 | - | Southampton FC U23 | 3:1 | |
Angleterre