| 1. Journée | 07.08.2021 | Crewe Alexandra | - | Cheltenham Town | 1:1 |  |
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| 2. Journée | 14.08.2021 | Portsmouth FC | - | Crewe Alexandra | 2:0 | ||||
| 3. Journée | 17.08.2021 | Oxford United | - | Crewe Alexandra | 1:0 | ||||
| 4. Journée | 21.08.2021 | Crewe Alexandra | - | Accrington Stanley | 0:1 | |
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| 5. Journée | 28.08.2021 | Charlton Athletic | - | Crewe Alexandra | 2:0 | ||||
| 7. Journée | 11.09.2021 | Shrewsbury Town | - | Crewe Alexandra | 1:1 | |
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| 8. Journée | 18.09.2021 | Crewe Alexandra | - | Burton Albion | 2:0 | ||||
| 6. Journée | 21.09.2021 | Crewe Alexandra | - | Morecambe FC | 1:3 | ||||
| 9. Journée | 25.09.2021 | Rotherham United | - | Crewe Alexandra | 1:1 | ||||
| 10. Journée | 28.09.2021 | Plymouth Argyle | - | Crewe Alexandra | 1:1 | ||||
| 11. Journée | 02.10.2021 | Crewe Alexandra | - | Cambridge United | 2:2 | |
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| 14. Journée | 19.10.2021 | Crewe Alexandra | - | Sunderland AFC | 0:4 | ||||
| 22. Journée | 11.12.2021 | Crewe Alexandra | - | Sheffield Wednesday | 0:2 | ||||
| 25. Journée | 29.12.2021 | Morecambe FC | - | Crewe Alexandra | 1:2 | ||||
| 26. Journée | 01.01.2022 | Burton Albion | - | Crewe Alexandra | 4:1 |
Angleterre