| 1. Journée | 08.08.2021 | Sporting San Miguelito | - | Alianza | 1:2 | ||||
| 5. Journée | 04.09.2021 | Árabe Unido | - | Sporting San Miguelito | 0:1 |  |
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| 7. Journée | 17.09.2021 | Independiente de La Chorrera | - | Sporting San Miguelito | 3:0 | ||||
| 8. Journée | 26.09.2021 | Veraguas Club Deportivo | - | Sporting San Miguelito | 2:0 | ||||
| 9. Journée | 03.10.2021 | Sporting San Miguelito | - | Herrera FC | 1:1 | ||||
| 10. Journée | 10.10.2021 | Sporting San Miguelito | - | San Francisco FC | 1:1 | ||||
| 11. Journée | 17.10.2021 | Atlético Chiriquí | - | Sporting San Miguelito | 1:1 | ||||
| 12. Journée | 23.10.2021 | Alianza | - | Sporting San Miguelito | 1:0 | ||||
| 13. Journée | 31.10.2021 | Sporting San Miguelito | - | Plaza Amador | 1:1 |  |
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| 14. Journée | 07.11.2021 | Tauro FC | - | Sporting San Miguelito | 1:0 | ||||
| 15. Journée | 13.11.2021 | Deportivo del Este | - | Sporting San Miguelito | 1:0 | |
Panama