| 2. Journée | 22.05.2021 | Boston River | - | Rentistas | 1:2 | ||||
| 3. Journée | 30.05.2021 | Peñarol | - | Boston River | 5:2 | ||||
| 4. Journée | 06.06.2021 | Boston River | - | Montevideo City Torque | 1:2 | ||||
| 5. Journée | 14.06.2021 | Villa Española | - | Boston River | 2:2 |  |
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| 6. Journée | 19.06.2021 | Boston River | - | Nacional | 1:1 | |
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| 7. Journée | 23.06.2021 | Cerrito | - | Boston River | 1:0 | ||||
| 8. Journée | 27.06.2021 | Boston River | - | Liverpool | 1:1 | ||||
| 9. Journée | 03.07.2021 | River Plate | - | Boston River | 1:1 | ||||
| 11. Journée | 16.07.2021 | Progreso | - | Boston River | 1:0 | ||||
| 14. Journée | 16.08.2021 | Boston River | - | Fénix | 0:2 |
Uruguay