| 01.08.21 | Santos Laguna [U20] | - | Cruz Azul [U20] | 1:0 |  |
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| 21.08.21 | Club León [U20] | - | Santos Laguna [U20] | 1:1 | |||||
| 02.10.21 | Santos Laguna [U20] | - | Mazatlán FC [U20] | 4:2 | |
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| 12.02.22 | Santos Laguna [U20] | - | CF América [U20] | 0:0 | |||||
| 02.03.22 | Santos Laguna [U20] | - | Pumas UNAM [U20] | 2:1 | |||||
| 18.08.22 | Santos Laguna [U20] | - | Club León [U20] | 2:3 | |||||
| 06.09.22 | Santos Laguna [U20] | - | Club Necaxa [U20] | 3:2 | |
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| 09.04.23 | Santos Laguna [U20] | - | CF Pachuca [U20] | 1:3 | |||||
| 19.04.23 | Santos Laguna [U20] | - | Deportivo Toluca [U20] | 2:1 | |
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| 03.05.23 | Santos Laguna [U20] | - | Deportivo Guadalajara [U20] | 3:4 | |
Mexique