| 8. Journée | 10.07.2021 | Real Potosí | - | The Strongest | 1:3 | ||||
| 16. Journée | 18.08.2021 | The Strongest | - | Nacional Potosí | 7:0 | ||||
| 17. Journée | 21.08.2021 | Oriente Petrolero | - | The Strongest | 2:0 |  |
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| 19. Journée | 19.09.2021 | The Strongest | - | Jorge Wilstermann | 3:1 | |
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| 20. Journée | 23.09.2021 | Atlético Palmaflor | - | The Strongest | 0:0 | ||||
| 21. Journée | 27.09.2021 | The Strongest | - | Always Ready | 1:1 | ||||
| 22. Journée | 19.10.2021 | Royal Pari | - | The Strongest | 0:1 | ||||
| 23. Journée | 23.10.2021 | The Strongest | - | Real Potosí | 1:0 | ||||
| 24. Journée | 26.10.2021 | CD Guabirá | - | The Strongest | 0:0 | ||||
| 25. Journée | 30.10.2021 | The Strongest | - | Blooming | 2:1 | ||||
| 27. Journée | 26.11.2021 | The Strongest | - | Club Aurora | 3:0 | ||||
| 29. Journée | 05.12.2021 | The Strongest | - | Club San José | 2:0 |
Bolivie