| 1er tour | 18.03.2021 | Cortuluá | - | Real Santander | 1:2 | ||||
| 2e tour | 15.04.2021 | Leones FC | - | Real Santander | 1:3 |  |
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| 2e tour | 21.04.2021 | Real Santander | - | Leones FC | 2:0 | ||||
| 3e tour | 28.07.2021 | Patriotas FC | - | Real Santander | 1:0 | ||||
| 3e tour | 04.08.2021 | Real Santander | - | Patriotas FC | 4:5 tab |
Colombie