| 2. Journée | 21.02.2021 | River Plate | - | Rosario Central | 3:0 | ||||
| 3. Journée | 28.02.2021 | Platense | - | River Plate | 0:1 | ||||
| 4. Journée | 09.03.2021 | River Plate | - | Argentinos Juniors | 0:1 | ||||
| 5. Journée | 14.03.2021 | Boca Juniors | - | River Plate | 1:1 | ||||
| 6. Journée | 21.03.2021 | Godoy Cruz | - | River Plate | 1:6 |  |
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| 7. Journée | 28.03.2021 | River Plate | - | Racing Club | 0:0 | ||||
| 8. Journée | 04.04.2021 | Arsenal de Sarandí | - | River Plate | 0:0 | ||||
| 9. Journée | 12.04.2021 | River Plate | - | Colón de Santa Fe | 3:2 | ||||
| 10. Journée | 17.04.2021 | Central Córdoba SdE | - | River Plate | 0:5 | ||||
| 11. Journée | 25.04.2021 | River Plate | - | San Lorenzo | 1:2 | |
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| 12. Journée | 02.05.2021 | Banfield | - | River Plate | 1:0 | ||||
| 13. Journée | 09.05.2021 | River Plate | - | Aldosivi | 4:1 |
Colombie