| 3. Journée | 18.09.2021 | FC Emmen [U21] | - | Willem II [U21] | 3:4 | ||||
| 4. Journée | 25.09.2021 | Willem II [U21] | - | Alphense Boys [U21] | 5:2 |  |
|||
| 6. Journée | 16.10.2021 | Willem II [U21] | - | De Graafschap [U21] | 1:2 | ||||
| 8. Journée | 31.10.2021 | Willem II [U21] | - | Roda JC Kerkrade [U21] | 1:0 | ||||
| 9. Journée | 06.11.2021 | Alphense Boys [U21] | - | Willem II [U21] | 0:3 |
Pays-Bas