| 2. Journée | 12.02.2022 | Plaza Colonia | - | River Plate | 0:1 | ||||
| 3. Journée | 19.02.2022 | River Plate | - | Boston River | 1:2 | ||||
| 4. Journée | 28.02.2022 | River Plate | - | Cerrito | 3:1 | ||||
| 5. Journée | 05.03.2022 | River Plate | - | Cerro Largo | 1:1 |  |
|||
| 6. Journée | 20.03.2022 | River Plate | - | Fénix | 3:1 | ||||
| 7. Journée | 03.04.2022 | Defensor Sporting | - | River Plate | 3:2 | ||||
| 8. Journée | 10.04.2022 | River Plate | - | Albion | 4:1 | ||||
| 9. Journée | 17.04.2022 | Nacional | - | River Plate | 1:1 | ||||
| 10. Journée | 23.04.2022 | River Plate | - | Danubio | 0:0 | ||||
| 11. Journée | 07.05.2022 | Deportivo Maldonado | - | River Plate | 2:1 | ||||
| 12. Journée | 13.05.2022 | River Plate | - | Rentistas | 1:0 | ||||
| 13. Journée | 22.05.2022 | Liverpool | - | River Plate | 2:1 | ||||
| 14. Journée | 29.05.2022 | River Plate | - | Peñarol | 0:0 |
Uruguay
Espagne