| 2. Journée | 17.05.2021 | Rio Grande Valley FC | - | San Antonio FC | 2:1 | ||||
| 2. Journée | 23.05.2021 | El Paso Locomotive | - | Rio Grande Valley FC | 1:0 | ||||
| 2. Journée | 30.05.2021 | San Antonio FC | - | Rio Grande Valley FC | 1:1 |  |
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| 3. Journée | 07.06.2021 | Miami FC | - | Rio Grande Valley FC | 2:4 | ||||
| 3. Journée | 13.06.2021 | Rio Grande Valley FC | - | Real Monarchs SLC | 1:0 | |
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| 3. Journée | 17.06.2021 | Rio Grande Valley FC | - | Austin Bold | 1:2 | ||||
| 3. Journée | 20.06.2021 | San Antonio FC | - | Rio Grande Valley FC | 1:1 | |
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| 4. Journée | 08.07.2021 | Austin Bold | - | Rio Grande Valley FC | 1:1 | ||||
| 4. Journée | 18.07.2021 | Orange County SC | - | Rio Grande Valley FC | 0:2 | ||||
| 4. Journée | 25.07.2021 | Rio Grande Valley FC | - | Austin Bold | 1:1 | ||||
| 5. Journée | 05.08.2021 | Real Monarchs SLC | - | Rio Grande Valley FC | 0:3 |  |
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| 5. Journée | 09.08.2021 | Rio Grande Valley FC | - | San Antonio FC | 1:2 | ||||
| 5. Journée | 18.08.2021 | Austin Bold | - | Rio Grande Valley FC | 1:1 | ||||
| 5. Journée | 22.08.2021 | El Paso Locomotive | - | Rio Grande Valley FC | 3:1 |
Colombie