| 1. Journée | 22.02.2021 | Alianza | - | Sporting San Miguelito | 0:0 |  |
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| 2. Journée | 28.02.2021 | Sporting San Miguelito | - | Plaza Amador | 0:0 | ||||
| 3. Journée | 08.03.2021 | Tauro FC | - | Sporting San Miguelito | 0:1 | ||||
| 7. Journée | 24.03.2021 | Sporting San Miguelito | - | Independiente de La Chorrera | 1:3 | ||||
| 8. Journée | 29.03.2021 | Sporting San Miguelito | - | Veraguas Club Deportivo | 1:1 | ||||
| 9. Journée | 05.04.2021 | Herrera FC | - | Sporting San Miguelito | 2:0 | ||||
| 11. Journée | 17.04.2021 | Sporting San Miguelito | - | Atlético Chiriquí | 2:1 | ||||
| 12. Journée | 21.04.2021 | Sporting San Miguelito | - | Alianza | 0:0 | ||||
| 13. Journée | 25.04.2021 | Plaza Amador | - | Sporting San Miguelito | 2:1 | ||||
| 14. Journée | 28.04.2021 | Sporting San Miguelito | - | Tauro FC | 2:2 | ||||
| 15. Journée | 06.05.2021 | Sporting San Miguelito | - | Deportivo del Este | 1:0 | ||||
| 16. Journée | 09.05.2021 | Árabe Unido | - | Sporting San Miguelito | 1:2 | |
Panama