| Quarts de finale | 26.11.2021 | Puebla FC | - | Club León | 2:1 | ||||
| Quarts de finale | 29.11.2021 | Club León | - | Puebla FC | 2:0 | ||||
| Demi-finales | 02.12.2021 | UANL Tigres | - | Club León | 2:1 |  |
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| Demi-finales | 05.12.2021 | Club León | - | UANL Tigres | 2:1 | ||||
| Finale | 10.12.2021 | Club León | - | Atlas Guadalajara | 3:2 | ||||
| Finale | 13.12.2021 | Atlas Guadalajara | - | Club León | 4:3 tab |  |
Chili