| 1. Journée | 23.02.2025 | St. Louis City SC | - | Colorado Rapids | 0:0 | ||||
| 2. Journée | 02.03.2025 | San Diego FC | - | St. Louis City SC | 0:0 | ||||
| 3. Journée | 10.03.2025 | Los Angeles Galaxy | - | St. Louis City SC | 0:3 |  |
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| 4. Journée | 16.03.2025 | St. Louis City SC | - | Seattle Sounders | 1:0 | ||||
| 5. Journée | 23.03.2025 | Philadelphia Union | - | St. Louis City SC | 1:0 | ||||
| 6. Journée | 30.03.2025 | St. Louis City SC | - | Austin FC | 0:1 | |
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| 10. Journée | 28.04.2025 | Los Angeles FC | - | St. Louis City SC | 2:2 | ||||
| 11. Journée | 04.05.2025 | Seattle Sounders | - | St. Louis City SC | 4:1 | ||||
| 12. Journée | 11.05.2025 | St. Louis City SC | - | San Diego FC | 1:2 |
Allemagne