| 1. Journée | 28.08.2021 | FC Groningen [U21] | - | NEC Nijmegen [U21] | 2:1 |  |
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| 2. Journée | 11.09.2021 | Almere City FC [U21] | - | FC Groningen [U21] | 1:2 | |
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| 3. Journée | 18.09.2021 | FC Groningen [U21] | - | Feyenoord [U21] | 2:1 | ||||
| 4. Journée | 25.09.2021 | sc Heerenveen [U21] | - | FC Groningen [U21] | 4:2 | ||||
| 5. Journée | 02.10.2021 | FC Groningen [U21] | - | NAC Breda [U21] | 1:2 | ||||
| 6. Journée | 16.10.2021 | Twente/Heracles [U21] | - | FC Groningen [U21] | 1:2 | ||||
| 7. Journée | 23.10.2021 | FC Groningen [U21] | - | ADO Den Haag [U21] | 2:1 | ||||
| 8. Journée | 30.10.2021 | NAC Breda [U21] | - | FC Groningen [U21] | 0:2 | ||||
| 10. Journée | 20.11.2021 | ADO Den Haag [U21] | - | FC Groningen [U21] | 4:2 | ||||
| 11. Journée | 27.11.2021 | FC Groningen [U21] | - | Almere City FC [U21] | 3:0 | ||||
| 12. Journée | 12.02.2022 | NEC Nijmegen [U21] | - | FC Groningen [U21] | 1:1 |
Pays-Bas