| tour des 16 | 08.04.2021 | Deportivo Saprissa | - | Philadelphia Union | 0:1 |  |
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| tour des 16 | 15.04.2021 | Philadelphia Union | - | Deportivo Saprissa | 4:0 | ||||
| Quarts de finale | 28.04.2021 | Atlanta United FC | - | Philadelphia Union | 0:3 | ||||
| Quarts de finale | 05.05.2021 | Philadelphia Union | - | Atlanta United FC | 1:1 | ||||
| Demi-finales | 13.08.2021 | CF América | - | Philadelphia Union | 2:0 | ||||
| Demi-finales | 16.09.2021 | Philadelphia Union | - | CF América | 0:2 | |
Norvège