| 2. Journée | 01.05.2021 | Phoenix Rising | - | San Diego Loyal | 4:1 | ||||
| 2. Journée | 07.05.2021 | Rio Grande Valley FC | - | San Diego Loyal | 1:0 |  |
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| 2. Journée | 14.05.2021 | Tacoma Defiance | - | San Diego Loyal | 3:1 |  |
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| 2. Journée | 23.05.2021 | Louisville City FC | - | San Diego Loyal | 2:1 | ||||
| 2. Journée | 30.05.2021 | San Diego Loyal | - | Las Vegas Lights FC | 2:1 | ||||
| 3. Journée | 06.06.2021 | Phoenix Rising | - | San Diego Loyal | 2:2 | ||||
| 3. Journée | 10.06.2021 | Orange County SC | - | San Diego Loyal | 1:1 | ||||
| 3. Journée | 13.06.2021 | San Diego Loyal | - | Los Angeles Galaxy II | 2:1 | ||||
| 3. Journée | 20.06.2021 | San Diego Loyal | - | Phoenix Rising | 2:1 | |
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| 3. Journée | 26.06.2021 | Las Vegas Lights FC | - | San Diego Loyal | 1:2 | ||||
| 3. Journée | 30.06.2021 | San Diego Loyal | - | Oakland Roots | 1:0 | ||||
| 4. Journée | 04.07.2021 | San Diego Loyal | - | Sacramento Republic | 1:1 | ||||
| 4. Journée | 15.07.2021 | San Diego Loyal | - | Orange County SC | 2:1 | ||||
| 4. Journée | 25.07.2021 | San Diego Loyal | - | Phoenix Rising | 0:1 | ||||
| 4. Journée | 30.07.2021 | Tacoma Defiance | - | San Diego Loyal | 2:1 | ||||
| 5. Journée | 02.08.2021 | Los Angeles Galaxy II | - | San Diego Loyal | 0:2 |
Angleterre