| 1. Journée | 13.08.2021 | NK Sesvete | - | NK Osijek II | 1:4 | ||||
| 2. Journée | 20.08.2021 | NK Osijek II | - | Dinamo Zagreb II | 1:1 | ||||
| 4. Journée | 10.09.2021 | NK Osijek II | - | NK Solin | 3:2 |  |
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| 5. Journée | 15.09.2021 | NK Dubrava | - | NK Osijek II | 3:0 | ||||
| 6. Journée | 19.09.2021 | NK Osijek II | - | NK Croatia Zmijavci | 1:2 | ||||
| 7. Journée | 26.09.2021 | HNK Orijent Rijeka | - | NK Osijek II | 0:1 |  |
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| 8. Journée | 02.10.2021 | NK Osijek II | - | NK Opatija | 0:2 | ||||
| 9. Journée | 16.10.2021 | HNK Cibalia | - | NK Osijek II | 1:0 | ||||
| 14. Journée | 27.11.2021 | NK Osijek II | - | NK Jarun | 0:0 | ||||
| 15. Journée | 05.12.2021 | NK BSK Bijelo Brdo | - | NK Osijek II | 0:2 | ||||
| 18. Journée | 26.02.2022 | NK Osijek II | - | NK Dugopolje | 2:0 | ||||
| 19. Journée | 05.03.2022 | NK Solin | - | NK Osijek II | 0:0 | ||||
| 26. Journée | 02.05.2022 | NK Osijek II | - | NK Inter Zaprešić | 1:2 | ||||
| 27. Journée | 07.05.2022 | NK Rudeš | - | NK Osijek II | 1:0 | ||||
| 28. Journée | 16.05.2022 | NK Osijek II | - | NK Kustošija | 0:1 | ||||
| 29. Journée | 21.05.2022 | NK Jarun | - | NK Osijek II | 3:0 | ||||
| 30. Journée | 28.05.2022 | NK Osijek II | - | NK BSK Bijelo Brdo | 1:1 |
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