| 1. Journée | 15.05.2021 | Montevideo Wanderers | - | Boston River | 1:0 |  |
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| 2. Journée | 22.05.2021 | Boston River | - | Rentistas | 1:2 | |
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| 3. Journée | 30.05.2021 | Peñarol | - | Boston River | 5:2 | ||||
| 4. Journée | 06.06.2021 | Boston River | - | Montevideo City Torque | 1:2 | ||||
| 5. Journée | 14.06.2021 | Villa Española | - | Boston River | 2:2 | |
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| 6. Journée | 19.06.2021 | Boston River | - | Nacional | 1:1 | ||||
| 7. Journée | 23.06.2021 | Cerrito | - | Boston River | 1:0 | |
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| 15. Journée | 21.08.2021 | Deportivo Maldonado | - | Boston River | 0:2 |
Uruguay