| 3. Journée | 29.01.2021 | Boston River | - | Cerro Largo | 2:1 | ||||
| 4. Journée | 04.02.2021 | Montevideo Wanderers | - | Boston River | 2:2 | ||||
| 6. Journée | 11.02.2021 | River Plate | - | Boston River | 3:1 | ||||
| 7. Journée | 15.02.2021 | Boston River | - | Montevideo City Torque | 0:3 | ||||
| 10. Journée | 28.02.2021 | Fénix | - | Boston River | 2:1 | ||||
| 14. Journée | 25.03.2021 | Nacional | - | Boston River | 1:2 | ||||
| 15. Journée | 29.03.2021 | Boston River | - | Liverpool | 1:0 |
Uruguay