| 1. Journée | 01.07.2021 | FC Floreşti | - | CS Petrocub | 0:1 | ||||
| 2. Journée | 17.07.2021 | FC Zimbru | - | FC Floreşti | 4:0 | ||||
| 3. Journée | 24.07.2021 | FC Floreşti | - | Dinamo-Auto | 0:1 | ||||
| 4. Journée | 31.07.2021 | FC Floreşti | - | FC Sheriff | 1:3 | ||||
| 5. Journée | 08.08.2021 | FC Milsami | - | FC Floreşti | 4:1 | ||||
| 6. Journée | 15.08.2021 | FC Floreşti | - | FC Sfîntul Gheorghe | 1:5 | ||||
| 7. Journée | 20.08.2021 | FC Bălţi | - | FC Floreşti | 3:1 |  |
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| 8. Journée | 25.08.2021 | CS Petrocub | - | FC Floreşti | 2:0 | ||||
| 9. Journée | 11.09.2021 | FC Floreşti | - | FC Zimbru | 1:3 | ||||
| 10. Journée | 18.09.2021 | Dinamo-Auto | - | FC Floreşti | 1:0 | ||||
| 11. Journée | 22.09.2021 | FC Sheriff | - | FC Floreşti | 4:0 | ||||
| 12. Journée | 26.09.2021 | FC Floreşti | - | FC Milsami | 0:3 | ||||
| 13. Journée | 01.10.2021 | FC Sfîntul Gheorghe | - | FC Floreşti | 4:1 | ||||
| 14. Journée | 16.10.2021 | FC Floreşti | - | FC Bălţi | 1:3 | ||||
| 15. Journée | 23.10.2021 | FC Floreşti | - | CS Petrocub | 3:4 |  |
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| 16. Journée | 30.10.2021 | FC Zimbru | - | FC Floreşti | 3:0 | ||||
| 17. Journée | 06.11.2021 | FC Floreşti | - | Dinamo-Auto | 1:5 | ||||
| 18. Journée | 20.11.2021 | FC Floreşti | - | FC Sheriff | 1:3 | |
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| 19. Journée | 28.11.2021 | FC Milsami | - | FC Floreşti | 5:0 |
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