| 1. Journée | 16.01.2021 | Danubio | - | Cerro Largo | 0:3 | ||||
| 2. Journée | 20.01.2021 | Cerro Largo | - | Nacional | 0:0 | ||||
| 3. Journée | 29.01.2021 | Boston River | - | Cerro Largo | 2:1 |  |
|||
| 4. Journée | 02.02.2021 | Cerro Largo | - | Deportivo Maldonado | 1:2 |  |
|||
| 5. Journée | 06.02.2021 | Rentistas | - | Cerro Largo | 2:1 | |
|||
| 6. Journée | 10.02.2021 | Liverpool | - | Cerro Largo | 3:2 | |
|
||
| 7. Journée | 13.02.2021 | Cerro Largo | - | Montevideo Wanderers | 1:3 | |
|||
| 8. Journée | 17.02.2021 | Cerro Largo | - | Peñarol | 1:1 | ||||
| 9. Journée | 20.02.2021 | River Plate | - | Cerro Largo | 2:0 |  |
|||
| 11. Journée | 07.03.2021 | Cerro Largo | - | Plaza Colonia | 3:1 | |
|||
| 12. Journée | 14.03.2021 | Cerro Largo | - | Progreso | 1:0 | ||||
| 13. Journée | 21.03.2021 | Fénix | - | Cerro Largo | 1:0 |  |
Uruguay