| 1. Journée | 12.09.2021 | Boston River | - | Montevideo Wanderers | 1:3 |  |
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| 2. Journée | 20.09.2021 | Deportivo Maldonado | - | Montevideo Wanderers | 1:3 | ||||
| 3. Journée | 26.09.2021 | Montevideo Wanderers | - | Rentistas | 2:1 | |
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| 4. Journée | 04.10.2021 | Peñarol | - | Montevideo Wanderers | 3:0 | ||||
| 5. Journée | 09.10.2021 | Montevideo Wanderers | - | Montevideo City Torque | 0:1 | ||||
| 6. Journée | 17.10.2021 | Villa Española | - | Montevideo Wanderers | 2:2 | |
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| 7. Journée | 22.10.2021 | Montevideo Wanderers | - | Nacional | 1:0 | ||||
| 8. Journée | 24.10.2021 | Cerrito | - | Montevideo Wanderers | 2:2 |  |
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| 10. Journée | 03.11.2021 | River Plate | - | Montevideo Wanderers | 0:1 | ||||
| 11. Journée | 08.11.2021 | Montevideo Wanderers | - | Cerro Largo | 1:2 | ||||
| 12. Journée | 15.11.2021 | Progreso | - | Montevideo Wanderers | 3:1 | ||||
| 13. Journée | 19.11.2021 | Montevideo Wanderers | - | Sud América | 4:1 | |
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| 14. Journée | 26.11.2021 | Plaza Colonia | - | Montevideo Wanderers | 0:1 | ||||
| 15. Journée | 04.12.2021 | Montevideo Wanderers | - | Fénix | 1:1 |
Argentine