| 1. Journée | 31.08.2016 | Boston River | - | Defensor Sporting | 1:1 | ||||
| 2. Journée | 04.09.2016 | Defensor Sporting | - | Juventud de Las Piedras | 0:1 | ||||
| 5. Journée | 24.09.2016 | Defensor Sporting | - | CA Cerro | 0:1 | ||||
| 6. Journée | 02.10.2016 | Defensor Sporting | - | Montevideo Wanderers | 1:1 | ||||
| 7. Journée | 09.10.2016 | Fénix | - | Defensor Sporting | 3:1 | ||||
| 8. Journée | 16.10.2016 | Defensor Sporting | - | Liverpool | 1:3 | ||||
| 10. Journée | 29.10.2016 | Rampla Juniors | - | Defensor Sporting | 0:1 | ||||
| 11. Journée | 12.11.2016 | Villa Española | - | Defensor Sporting | 2:2 |  |
Uruguay