| 2. Journée | 14.08.2021 | Birmingham City | - | Stoke City | 0:0 | ||||
| 3. Journée | 17.08.2021 | Swansea City | - | Stoke City | 1:3 | ||||
| 4. Journée | 21.08.2021 | Stoke City | - | Nottingham Forest | 1:0 |  |
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| 5. Journée | 28.08.2021 | Fulham FC | - | Stoke City | 3:0 | ||||
| 6. Journée | 11.09.2021 | Stoke City | - | Huddersfield Town | 2:1 | ||||
| 7. Journée | 15.09.2021 | Stoke City | - | Barnsley FC | 1:1 | ||||
| 8. Journée | 18.09.2021 | Derby County | - | Stoke City | 2:1 | ||||
| 9. Journée | 25.09.2021 | Stoke City | - | Hull City | 2:0 | ||||
| 10. Journée | 28.09.2021 | Preston North End | - | Stoke City | 1:1 | ||||
| 11. Journée | 01.10.2021 | Stoke City | - | West Bromwich Albion | 1:0 | ||||
| 12. Journée | 16.10.2021 | Sheffield United | - | Stoke City | 2:1 | ||||
| 13. Journée | 19.10.2021 | Stoke City | - | AFC Bournemouth | 0:1 | ||||
| 14. Journée | 23.10.2021 | Millwall FC | - | Stoke City | 2:1 | |
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| 15. Journée | 30.10.2021 | Stoke City | - | Cardiff City | 3:3 | |
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| 16. Journée | 03.11.2021 | Blackpool FC | - | Stoke City | 0:1 | ||||
| 17. Journée | 06.11.2021 | Luton Town | - | Stoke City | 0:1 |
Écosse