| 1. Journée | 18.07.2021 | Club Olimpia | - | River Plate | 1:3 | ||||
| 8. Journée | 12.09.2021 | Sportivo Luqueño | - | River Plate | 0:2 | ||||
| 9. Journée | 18.09.2021 | River Plate | - | Libertad | 0:1 | ||||
| 13. Journée | 23.10.2021 | River Plate | - | Sol de América | 0:2 | ||||
| 14. Journée | 30.10.2021 | Club Nacional | - | River Plate | 1:1 |
Uruguay