| 1. Journée | 18.01.2021 | Defensor Sporting | - | Montevideo Wanderers | 1:1 | ||||
| 2. Journée | 28.01.2021 | Peñarol | - | Defensor Sporting | 1:2 | ||||
| 7. Journée | 15.02.2021 | Defensor Sporting | - | Fénix | 2:2 | ||||
| 8. Journée | 18.02.2021 | CA Cerro | - | Defensor Sporting | 0:0 | ||||
| 11. Journée | 08.03.2021 | Nacional | - | Defensor Sporting | 2:1 | ||||
| 12. Journée | 12.03.2021 | Defensor Sporting | - | Boston River | 1:2 |
Uruguay