| 2e tour | 23.02.2022 | Plaza Colonia | - | The Strongest | 2:0 | ||||
| 2e tour | 02.03.2022 | The Strongest | - | Plaza Colonia | 3:0 |  |
|||
| 3e tour | 11.03.2022 | Universidad Catolica | - | The Strongest | 0:0 | ||||
| 3e tour | 18.03.2022 | The Strongest | - | Universidad Catolica | 2:1 | ||||
| Groupe B | 08.04.2022 | The Strongest | - | Libertad | 1:1 | ||||
| Groupe B | 15.04.2022 | Athletico Paranaense | - | The Strongest | 1:0 | ||||
| Groupe B | 28.04.2022 | The Strongest | - | Caracas FC | 1:1 | ||||
| Groupe B | 04.05.2022 | The Strongest | - | Athletico Paranaense | 5:0 | ||||
| Groupe B | 18.05.2022 | Caracas FC | - | The Strongest | 0:0 |
Uruguay