| 6. Journée | 21.08.2022 | Defensor Sporting | - | Boston River | 0:1 | ||||
| 5. Journée | 28.08.2022 | Plaza Colonia | - | Defensor Sporting | 0:1 |  |
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| 4. Journée | 03.09.2022 | Defensor Sporting | - | Montevideo Wanderers | 1:0 | ||||
| 7. Journée | 11.09.2022 | River Plate | - | Defensor Sporting | 0:1 |  |
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| 10. Journée | 26.09.2022 | Cerrito | - | Defensor Sporting | 1:2 | ||||
| 11. Journée | 02.10.2022 | Defensor Sporting | - | Albion | 2:0 | ||||
| 12. Journée | 09.10.2022 | Nacional | - | Defensor Sporting | 1:1 | |
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| 15. Journée | 22.10.2022 | Defensor Sporting | - | Rentistas | 2:3 |
Uruguay