| 1. Journée | 29.08.2021 | Cesena FC | - | AS Gubbio | 0:0 | ||||
| 2. Journée | 05.09.2021 | AS Gubbio | - | Fermana FC | 1:0 | ||||
| 3. Journée | 12.09.2021 | AC Reggiana 1919 | - | AS Gubbio | 0:0 | ||||
| 4. Journée | 18.09.2021 | AS Gubbio | - | Virtus Entella | 3:1 | ||||
| 5. Journée | 25.09.2021 | US Grosseto FC | - | AS Gubbio | 1:1 |  |
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| 6. Journée | 28.09.2021 | AS Gubbio | - | Delfino Pescara | 2:2 | ||||
| 7. Journée | 03.10.2021 | Olbia Calcio | - | AS Gubbio | 1:0 | ||||
| 10. Journée | 19.10.2021 | AS Gubbio | - | Carrarese Calcio | 4:0 |  |
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| 11. Journée | 23.10.2021 | Vis Pesaro | - | AS Gubbio | 1:0 | ||||
| 12. Journée | 01.11.2021 | AS Gubbio | - | ACN Siena 1904 | 1:2 | ||||
| 13. Journée | 07.11.2021 | Imolese Calcio | - | AS Gubbio | 2:2 | ||||
| 14. Journée | 13.11.2021 | AS Gubbio | - | Lucchese | 0:0 | |
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| 16. Journée | 28.11.2021 | AS Gubbio | - | Ancona 1905 | 1:1 | |
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| 18. Journée | 12.12.2021 | Modena FC | - | AS Gubbio | 3:2 | ||||
| 20. Journée | 22.12.2021 | AS Gubbio | - | Cesena FC | 4:1 | ||||
| 23. Journée | 22.01.2022 | Virtus Entella | - | AS Gubbio | 4:0 | ||||
| 22. Journée | 23.02.2022 | AS Gubbio | - | AC Reggiana 1919 | 2:1 |
Italie