| 1. Journée | 12.02.2021 | Vélez Sarsfield II | - | Newell's Old Boys II | 3:0 | ||||
| 2. Journée | 19.02.2021 | Newell's Old Boys II | - | Boca Juniors II | 1:3 | ||||
| 3. Journée | 26.02.2021 | Talleres de Córdoba II | - | Newell's Old Boys II | 2:2 |  |
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| 4. Journée | 05.03.2021 | Newell's Old Boys II | - | Independiente II | 1:2 | ||||
| 5. Journée | 12.03.2021 | Defensa y Justicia II | - | Newell's Old Boys II | 2:1 | ||||
| 6. Journée | 19.03.2021 | Newell's Old Boys II | - | Unión de Santa Fe II | 3:1 | ||||
| 7. Journée | 26.03.2021 | Atlético Tucumán II | - | Newell's Old Boys II | 0:1 | ||||
| 8. Journée | 02.04.2021 | Newell's Old Boys II | - | Huracán II | 3:0 | ||||
| 9. Journée | 09.04.2021 | Lanús II | - | Newell's Old Boys II | 4:6 | ||||
| 10. Journée | 16.04.2021 | Newell's Old Boys II | - | Patronato de Paraná II | 1:0 | ||||
| 12. Journée | 30.04.2021 | Rosario Central II | - | Newell's Old Boys II | 0:2 |
Argentine