| 3. Journée | 02.03.2022 | Santiago Wanderers | - | Santiago Morning | 2:2 | ||||
| 4. Journée | 10.03.2022 | San Luis | - | Santiago Wanderers | 1:1 | ||||
| 5. Journée | 17.03.2022 | Santiago Wanderers | - | Rangers | 1:3 | ||||
| 8. Journée | 09.04.2022 | Deportes Copiapó | - | Santiago Wanderers | 1:1 | ||||
| 17. Journée | 28.05.2022 | Santa Cruz | - | Santiago Wanderers | 2:0 | ||||
| 1. Journée | 05.06.2022 | Santiago Wanderers | - | Deportes Iquique | 2:0 |  |
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| 11. Journée | 10.06.2022 | Santiago Wanderers | - | Unión San Felipe | 0:1 | ||||
| 18. Journée | 02.07.2022 | Deportes Iquique | - | Santiago Wanderers | 2:1 | |
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| 20. Journée | 15.07.2022 | Santiago Morning | - | Santiago Wanderers | 1:2 | ||||
| 21. Journée | 26.07.2022 | Santiago Wanderers | - | San Luis | 1:2 | ||||
| 31. Journée | 09.10.2022 | Santiago Wanderers | - | Cobreloa | 2:2 | ||||
| 32. Journée | 15.10.2022 | Universidad de Concepción | - | Santiago Wanderers | 1:1 | ||||
| 34. Journée | 02.11.2022 | Santiago Wanderers | - | Santa Cruz | 2:0 |
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