| 3. Journée | 27.07.2021 | Lanús II | - | River Plate II | 0:1 | ||||
| 4. Journée | 30.07.2021 | River Plate II | - | Huracán II | 2:0 | ||||
| 8. Journée | 23.08.2021 | River Plate II | - | Aldosivi II | 3:0 | ||||
| 12. Journée | 17.09.2021 | River Plate II | - | Arsenal de Sarandí II | 0:1 | ||||
| 16. Journée | 15.10.2021 | River Plate II | - | San Lorenzo II | 1:3 |  |
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| 20. Journée | 05.11.2021 | River Plate II | - | Patronato de Paraná II | 2:0 | ||||
| 22. Journée | 23.11.2021 | River Plate II | - | Racing Club II | 1:2 | ||||
| 23. Journée | 28.11.2021 | Rosario Central II | - | River Plate II | 2:0 |
Argentine